Achieving cross-reactivity with pan-ebolavirus antibodies
نویسندگان
چکیده
منابع مشابه
Neutralizing the Threat: Pan-Ebolavirus Antibodies Close the Loop.
The glycoprotein (GP) of ebolaviruses participates in a critical membrane fusion process to establish infection of a cell and therefore, represents an important target of both vaccines and antivirals. The latest reports on pan-ebolavirus monoclonal antibodies in small animal models may offer promising outcomes and insight into how best to target the GP in vaccine and antiviral discovery.
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UNLABELLED The unprecedented 2014-2015 Ebola virus disease (EVD) outbreak in West Africa has highlighted the need for effective therapeutics against filoviruses. Monoclonal antibody (MAb) cocktails have shown great potential as EVD therapeutics; however, the existing protective MAbs are virus species specific. Here we report the development of pan-ebolavirus and pan-filovirus antibodies generat...
متن کامل3. Antibodies and antigens: cross-reactivity before monoclonal antibodies 4. Antibodies and antigens: cross-reactivity after monoclonal antibodies 5. Cross-reactivity and the molecular mimicry hypothesis 6. Cross-reactivity and the phenomenon of microbial escape from immune surveillance
1. Abstract 2. Introduction: the “vaccine problem” 3. Antibodies and antigens: cross-reactivity before monoclonal antibodies 4. Antibodies and antigens: cross-reactivity after monoclonal antibodies 5. Cross-reactivity and the molecular mimicry hypothesis 6. Cross-reactivity and the phenomenon of microbial escape from immune surveillance 7. Peptide commonality, immune escape, adjuvanted vaccines...
متن کاملReston Ebolavirus Antibodies in Bats, the Philippines
To the Editor: Filoviruses cause highly lethal hemorrhagic fever in humans and nonhuman primates, except for Reston Ebolavirus (REBOV), which causes severe hemorrhagic fever in macaques (1,2). REBOV epizootics among cynomolgus macaques occurred in 1989, 1990, 1992, and 1996 (2) and among swine in 2008 (3). African fruit bats have been suggested to be natural reservoirs for Zaire Ebolavirus and ...
متن کاملDiscovery of an antibody for pan-ebolavirus therapy
During the latest outbreak of Ebola virus disease in West Africa, monoclonal antibody therapy (e.g., ZMapp) was utilized to treat patients. However, due to the antigenic differences among the five ebolavirus species, the current therapeutic monoclonal antibodies are only effective against viruses of the species Zaire ebolavirus. Although this particular species has indeed caused the majority of...
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ژورنال
عنوان ژورنال: Current Opinion in Virology
سال: 2019
ISSN: 1879-6257
DOI: 10.1016/j.coviro.2019.01.003